The main aim of this review was to provide insights on the possible cleaner production (CP) options for leather manufacturing industries and propose suitable resource recovery technologies. A real case study from local tanneries in Palestine has been presented. All the processes involved in the leather tannery industry have been reviewed based on raw materials, processing parameters and effluent composition. The evaluation of the identified CP options indicates that the most practical option is manipulating the processing parameters of the tanning process for increasing its efficiency. The high contents of COD in the released streams from beam house operations and of sulfides from the unhearing step also require attention. The different technological options for resource recovery, e.g. biogas, chromium, lipids and chemicals, from leather industry wastewater and solid wastes were reviewed and discussed.