The circular economy concept has gained momentum as a potential solution to resource scarcity and environmental sustainability. While most circular economy strategies focus on environmental and economic aspects, social factors such as labour practices, community well-being, and worker safety have received limited attention. This study examines the relationship between cleaner production, sustainability strategies, and CE safety across various activities. The findings provide insights for decision-makers pursuing sustainable development goals. An evaluation of cleaner production and sustainability strategies was conducted using the Best-Worst Method (BWM) and Interpretive Structural Modelling (ISM) techniques. The BWM analysis revealed “use of advanced automation and robotics” as the most significant strategy, followed by “sensors and monitoring systems” and “safety training and education”. ISM analysis generated a nine-level hierarchical model, demonstrating complex interconnections among twelve strategies. MICMAC analysis categorized these strategies into clusters, identifying five primary strategies as crucial drivers for safety enhancement. Notable findings include the dual confirmation of “use of advanced automation and robotics” as the highest-weighted and most influential strategy. The study revealed that “personal protective equipment innovation”, “eco-friendly chemical substitution”, and “waste reduction and management” strategies showed high dependence power but lower driving power. The findings provide practical implications for prioritizing and implementing safety strategies while advancing sustainable development goals. The study's approach offers insights for enhancing workplace safety within the circular economy paradigm.