The objective of this special issue is to showcase what Cleaner Production (CP) practitioners and scholars in Australia and New Zealand have accomplished to date, and how they hope to progress in the coming decades. The contributions to this special issue have been grouped under three main categories: sectoral, regional, and CP methods and tools. These contributions suggest that the CP debate has moved on from anecdotal justification of CP through case studies to diffusing and broadening CP practices so that they fulfil their role as effective components of a viable, sustainable society. The continued evolution of CP methods and tools in Australia and New Zealand is a good indicator of such a trend. Papers in all three categories identify and present responses to the challenges faced in ensuring that CP activities are both linked to and informed by policy-making and that they support and enhance decisions made in pursuit of sustainable production.